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Vaccine. 2019 Aug 28. pii: S0264-410X(19)31092-8. doi: 10.1016/j.vaccine.2019.08.028. [Epub ahead of print]
Cost-benefit analysis of a national influenza vaccination program in preventing hospitalisation costs in Australian adults aged 50-64 years old.
Raj SM1, Chughtai AA2, Sharma A2, Tan TC3, MacIntyre CR4.
Author information
1 Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: s.mahendraraj@unsw.edu.au. 2 School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Samuels Building, Sydney, NSW 2052, Australia. 3 Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Department of Cardiology, Blacktown Hospital, Blacktown, NSW 2148, Australia; School of Medicine, Western Sydney University, Sydney, NSW 2751, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia. 4 Biosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; College of Public Affairs and Community Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Abstract
INTRODUCTION:
Influenza causes a significant burden among Australian adults aged 50-64, however, vaccine coverage rates remain suboptimal. The National Immunisation Program (NIP) currently funds influenza vaccinations in this age group only for those at high risk of influenza complications.
AIMS:
The main aim of this study was to determine whether a strategy of expanding the government-funded vaccination program to all adults 50-64 in preventing influenza-related hospitalisations will be cost beneficial to the government.
METHODS:
A cost-benefit analysis from a governmental perspective was performed using parameters informed by publicly available databases and published literature. Costs included cost of vaccinations and general practitioner consultation while benefits included the savings from averted respiratory and acute myocardial infarction (AMI) hospitalisations.
RESULTS:
In the base-case scenario, the proposed policy would prevent 314 influenza/pneumonia, 388 other respiratory and 1482 AMI hospitalisations in a year. The government would save $8.03 million with an incremental benefit-cost ratio of 1.40. Most savings were due to averted AMI hospitalisations. In alternative scenarios cost savings ranged from saving of $31.4 million to additional cost to the government of $15.4 million, with sensitive variation in vaccine administration practices (through general practitioner or pharmacists) and vaccine effectiveness estimates.
DISCUSSION:
Extension of the NIP to include adults 50-64 years of age is likely to be cost beneficial to the government, although this finding is sensitive to vaccine administration cost, which varies if provided through general practitioners or pharmacists; and to variation in vaccine effectiveness. An increased role of pharmacists in immunisation programs would likely result in cost savings in an expanded adult immunisation program.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:
Cost-benefit analysis; Economic evaluation; Influenza; Vaccination
PMID: 31473001 DOI: 10.1016/j.vaccine.2019.08.028
Cost-benefit analysis of a national influenza vaccination program in preventing hospitalisation costs in Australian adults aged 50-64 years old.
Raj SM1, Chughtai AA2, Sharma A2, Tan TC3, MacIntyre CR4.
Author information
1 Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: s.mahendraraj@unsw.edu.au. 2 School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Samuels Building, Sydney, NSW 2052, Australia. 3 Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Department of Cardiology, Blacktown Hospital, Blacktown, NSW 2148, Australia; School of Medicine, Western Sydney University, Sydney, NSW 2751, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia. 4 Biosecurity Program, The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; College of Public Affairs and Community Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Abstract
INTRODUCTION:
Influenza causes a significant burden among Australian adults aged 50-64, however, vaccine coverage rates remain suboptimal. The National Immunisation Program (NIP) currently funds influenza vaccinations in this age group only for those at high risk of influenza complications.
AIMS:
The main aim of this study was to determine whether a strategy of expanding the government-funded vaccination program to all adults 50-64 in preventing influenza-related hospitalisations will be cost beneficial to the government.
METHODS:
A cost-benefit analysis from a governmental perspective was performed using parameters informed by publicly available databases and published literature. Costs included cost of vaccinations and general practitioner consultation while benefits included the savings from averted respiratory and acute myocardial infarction (AMI) hospitalisations.
RESULTS:
In the base-case scenario, the proposed policy would prevent 314 influenza/pneumonia, 388 other respiratory and 1482 AMI hospitalisations in a year. The government would save $8.03 million with an incremental benefit-cost ratio of 1.40. Most savings were due to averted AMI hospitalisations. In alternative scenarios cost savings ranged from saving of $31.4 million to additional cost to the government of $15.4 million, with sensitive variation in vaccine administration practices (through general practitioner or pharmacists) and vaccine effectiveness estimates.
DISCUSSION:
Extension of the NIP to include adults 50-64 years of age is likely to be cost beneficial to the government, although this finding is sensitive to vaccine administration cost, which varies if provided through general practitioners or pharmacists; and to variation in vaccine effectiveness. An increased role of pharmacists in immunisation programs would likely result in cost savings in an expanded adult immunisation program.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:
Cost-benefit analysis; Economic evaluation; Influenza; Vaccination
PMID: 31473001 DOI: 10.1016/j.vaccine.2019.08.028